Quality has its own way of coming through
                             	
								MARKOPOLO
Noise and/or ultrafine particulate matter induced cerebral and cardiovascular damage: novel insights from experimental and epidemiological brain-heart axis biomarkers and computational models
                                                Coordinator: Dr. rer. nat. et med. habil. Andreas Daiber, Universitätsmedizin der Johannes Gutenberg-Universität                                                                        									                                                                            
Funding scheme: Horizon Europe, 15 partners                                                                                                                
Duration: 48 months                                                                                                                
Start: 01.01.2025                                                                                                                
Objective: Air pollution (especially particulate matter) and traffic noise are major environmental hazards that can cause significant health problems. There are many knowledge gaps regarding the combined effects of air pollution and noise, particularly in vulnerable groups such as the elderly. The MARKOPOLO approach aims to address these gaps, identify relevant biomarkers, and understand molecular mechanisms to improve risk assessments.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination management                                                                                                                
Website: 
                                        												
																									
													https://markersofpollution-markopolo.eu/													
												                                                                        
                             	
								SP-EU
Social Prescribing to promote and improve access to health and care services for people in vulnerable situations in Europe
                                                Coordinator: Prof. Dr. med. Wolfram Herrmann, Charité - Universitätsmedizin Berlin                                                                        									                                                                            
Funding scheme: Horizon Europe, 22 partners                                                                                                                
Duration: 60 months                                                                                                                
Start: 01.01.2025                                                                                                                
Objective: The objective of SP-EU is to assess the potential of social prescribing (SP) to promote and improve access to health and care services for people in vulnerable situations, focusing on three primary target groups: LGBTIQ persons, refugees, and first-generation immigrants and older adults living alone. SP-EU will enable health care systems to implement SP as a scalable, safe, cost-effective and people-centred solution to provide equal access to sustainable care. Thus, SP-EU will enable the transformation of European health care systems to equitable, community-based, people-centred and integrated health care.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management                                                                                                                
Website: 
                                        												
																									
													https://social-prescribing.eu/													
												                                                                        
                             	
								PANCAID
PANcreatic CAncer Initial Detection via liquid biopsy
                                                Coordinator: Prof. Dr. med. Klaus Pantel, University Medical Center Hamburg-Eppendorf, Germany                                                                        									                                                                            
Funding scheme: Horizon Europe, 17 partners                                                                                                                 
Duration: 60 months                                                                                                                
Start: 01.01.2023                                                                                                                
Objective: As pancreatic cancer is usually detected at late stages and as most patients die within one year after diagnosis, the main objective of the PANCAID consortium is to develop and provide a minimally invasive blood test the for early detection of pancreatic cancer and the malignant conversion of premalignant to invasive lesions.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination management                                                                                                                
Website: 
                                        												
																									
													https://www.pancaid-project.eu/													
												                                                                        
                             	
								EMBRACE
EMBRACing changE: Overcoming obstacles and advancing democracy in the European Neighbourhood
                                                Coordinator: Dr. Véronique Dudouet                                                                        									                                                                            
Funding scheme: Horizon Europe, 14 partners                                                                                                                
Duration: 36 months                                                                                                                
Start:  01.10.2022                                                                                                                
Objective: EMBRACE analyses blockages to democratisation in the European neighbourhood, identifies ways to overcome them and suggests new policy tools for EU democracy promotion (EUDP). The aim is to take stock and assess the developments, instruments, ambitions and concepts of EU democracy promotion. Using a combined quantitative and qualitative research strategy, EMBRACE will develop an innovative policy toolkit to further develop existing EUDP instruments and identify new approaches for the EU. In this way, the research project aims to foster partnerships for a more stable and secure European neighbourhood and to create incentives for political actors to embrace democratic change.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management                                                                                                                
Website: 
                                        												
																									
													https://embrace-democracy.eu/													
												                                                                        
                             	
								FAMILY
Running in the FAMILY - Understanding and predicting the intergenerational transmission of mental illness
                                                Coordinator: Prof Neeltje van Haren, Erasmus MC                                                                        									                                                                            
Funding scheme: Horizon Europe, 18 partners                                                                                                                 
Duration: 60 months                                                                                                                
Start: 01.10.2022                                                                                                                
Objective: The FAMILY consortium aims to improve the lives of mentally ill people with novel predictive models.
In-depth causal analysis (how and when the risk of mental illness occurs) helps to identify risk and resilience factors early and in a family-based way, and to predict who may develop mental symptoms – serving as new targets for the development of prevention strategies.
Leistung von concentris: Coordination of the application, contract negotiations, project management, dissemination management
                                                                                                                                                    
Website: 
                                        												
																									
													https://family-project.eu													
												                                                                        
                             	
								RePo4EU
Precision drug REPurpOsing For EUrope and the world
                                                Coordinator: Prof. Dr Harald Schmidt, MD PhD PharmD, FESC, Maastricht University, The Netherlands                                                                        									                                                                            
Funding scheme: Horizon Europe, 28 Partners                                                                                                                
Duration: 84 months                                                                                                                
Start: 01.09.2022                                                                                                                
Objective: RePo4EU - A global innovative platform for repurposing already approved medicines. This reduces the time and cost of developing new therapies. Through systems medicine and AI, causal disease definitions are used, allowing more precise diagnoses. Patients participate to achieve the goals most relevant to them and thus make and shape their own decisions for their health.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations & project management in period 1                                                                                                                
Website: 
                                        												
																									
													https://repo4.eu/													
												                                                                        
                             	
								environMENTAL
Reducing the impact of major environmental challenges on mental health
                                                Coordinator: Prof. Dr. Gunter Schumann, Charité - Universitätsmedizin, Berlin                                                                        									                                                                            
Funding scheme: Horizon Europe, 24 partners                                                                                                                
Duration: 60 months                                                                                                                
Start: 01.06.2022                                                                                                                
Objective: environMENTAL is studying the impact of climate, pollution, urbanicity, regional socioeconomic conditions, as well as the Covid19 pandemic on brain health, and characterize its underlying biological mechanisms. The consortium will analyse data from more than one million European citizens and patients to uncover brain mechanisms linked to environmental adversity and leading to symptoms of depression, anxiety, stress and substance abuse.                                                                                                                
Services of concentris: Project management                                                                                                                
Website: 
                                        												
																									
													https://www.environmental-project.org/													
												                                                                        
                             	
								TIMESPAN
Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients
                                                Coordinator: Prof. Dr. Henrik Larsson (ORU)                                                                        									                                                                            
Funding scheme: Horizon2020, 17 partners                                                                                                                
Duration: 60 month                                                                                                                
Start: 01.04.2021                                                                                                                
Objective: Emerging evidence points at a significant association and shared genetic traits between adult attention-deficit/hyperactivity disorder (ADHD) and cardiometabolic conditions such as obesity, type 2 diabetes, and cardiovascular disease, which, when inadequately treated, can lead to adverse outcomes and significant costs for society. This is where TIMESPAN steps in, fostering improvements in risk stratification and improvement of the treatments already available for patients with ADHD who also have a cardiometabolic disease.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination management                                                                                                                
Website: 
                                        												
																									
													https://timespan.eu/													
												                                                                        
                             	
								A-TANGO
Novel treatment of acute-on-chronic liver failure using synergistic action of G-CSF and TAK-242
                                                Coordinator: Prof. Dr. Rajiv Jalan (EFCLIF)                                                                        									                                                                            
Funding scheme: Horizon2020, 14 partners                                                                                                                
Duration: 60 months                                                                                                                
Start: 01.03.2021                                                                                                                
Objective: In its final stages, decompensated cirrhosis leads to acute-on-chronic liver failure (ACLF), a syndrome characterised by multi-organ failure. The A-TANGO consortium performs Phase II clinical studies of an innovative therapeutic strategy for ACLF that repurposes an antagonist (TAK-242) of Toll-like receptor 4 (TLR4) in combination with granulocyte colony-stimulating factor (G-CSF). This novel combinatorial therapy is called “G-TAK”. In addition, A-TANGO strives to identify reliable biomarkers for better patient stratification and an increased survival rate.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination management                                                                                                                
Website: 
                                        												
																									
													https://a-tango.eu/													
												                                                                        
                             	
								FORTEe
Get strong to fight childhood cancer - an exercise intervention for children and adolescents undergoing anti-cancer treatment
                                                Coordinator: Univ.-Prof. Dr. med. Jörg Faber (UMC-Mainz)                                                                        									                                                                            
Funding scheme: Horizon2020, 16 partners                                                                                                                
Duration: 66 months                                                                                                                
Start: 01.03.2021                                                                                                                
Objective: FORTEe promotes exercise oncology that aims at making patients stronger to fight childhood cancer. Supervised exercise training intends to increase muscle strength and reduce muscular atrophy due to bed rest. Within the project, digital, innovative technologies such as augmented reality will be developed and applied to make the exercise training more effective, age-adapted and personalised. FORTEe has the ambition to implement paediatric exercise oncology as an evidence-based standard in clinical care for all childhood cancer patients across the EU and beyond.
                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination management                                                                                                                
Website: 
                                        												
																									
													https://fortee-project.eu/													
												                                                                        
                             	
								DECISION
DEcompensated CIrrhoSIs: Identification of new cOmbiNatorial therapies based on systems approaches
                                                Coordinator: Prof. Dr. Pierre-Emmanuel Ratou (APHP, EFCLIF, INSERM)                                                                        									                                                                            
Funding scheme: Horizon2020, 21 partners                                                                                                                
Duration: 66 months                                                                                                                
Start: 01.04.2020                                                                                                                
Objective: DECISION's objective is to better understand the pathophysiology of decompensated cirrhosis leading to acute-on-chronic liver failure (ACLF) or death. The project's research consortium takes advantage of many already existing biosamples and clinically well-characterized patient cohorts to develop prognostic and response tests and combinatorial therapies tailored to the needs of individual patients. The primary goal is to significantly decrease the mortality rate for end-stage liver cirrhosis in Europe.
                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination management                                                                                                                
Website: 
                                        												
																									
													https://decision-for-liver.eu/													
												                                                                        
                             	
								QSPainRelief
Effective combinational treatment of chronic pain in individual patients by an innovative quantitative systems pharmacology pain relief approach
                                                Coordinator: Prof. Dr. Elizabeth CM de Lange (ULEI)                                                                        									                                                                            
Funding scheme: Horizon2020, 10 partners                                                                                                                
Duration: 60 months                                                                                                                
Start: 01.01.2020                                                                                                                
Objective: QSPainRelief aims to develop effective drug combination treatments for the improved relief of chronic pain.  A quantitative systems pharmacology (QSP) mathematical modelling approach will be used to identify and validate more effective therapeutic interventions by smart combinations of existing drugs. The ultimate goal is to personalise and maximize pain relief for individuals suffering from chronic pain while diminishing side effects.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination management                                                                                                                
Website: 
                                        												
																									
													https://www.qspainrelief.eu/													
												                                                                        
                             	
								PRIME
Prevention and Remediation of Insulin Multimorbidity in Europe
                                                Coordinator: Prof. Dr. Barbara Franke (RUMC)                                                                        									                                                                            
Funding scheme: Horizon2020, 17 partners                                                                                                                
Duration: 60 months                                                                                                                
Start: 01.01.2020                                                                                                                
Objective: PRIME addresses insulin-related signalling as a novel, key-modulator of comorbid mental and non-mental diseases, and aims at generating innovative diagnostic and treatment strategies to improve the monitoring and clinical outcomes of patients. The project is aiming to increase the understanding of causal mechanisms underlying insulin-related multimorbidity and improving the management of insulin multimorbidity across the lifespan by developing intervention and preventative strategies.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination                                                                                                                
Website: 
                                        												
																									
													https://prime-study.eu/													
												                                                                        
                             	
								GO-DS21
Gene overdosage and comorbidities during the early lifetime in Down Syndrome
                                                Coordinator: Dr. Yann Herault (CERBM)                                                                        									                                                                            
Funding scheme: Horizon2020, 12 participants                                                                                                                
Duration: 66 months                                                                                                                
Start: 01.01.2020                                                                                                                
Objective: The overarching aim of GO-DS21 is to elucidate etiological mechanisms involved in the common morbidities of obesity and intellectual disability.  GO-DS21 will explore how intrinsic (genetic and pathway-driven) and extrinsic (environmental and epigenetic) factors can lead to such comorbid states.                                                                                                                 
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination                                                                                                                
Website: 
                                        												
																									
													https://www.go-ds21.eu/													
												                                                                        
                             	
								MICROB-PREDICT
MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response
                                                Coordinator: Prof. Dr. Jonel Trebicka, European Foundation for the Study of Chronic Liver Failure (EF-Clif)                                                                        									                                                                            
Funding scheme: Horizon2020, 22 participants                                                                                                                
Duration: 75 months                                                                                                                 
Start: 01.01.2019                                                                                                                 
Objective: MICROB-PREDICT investigates the human microbiome to identify predictors and mechanisms associated with the development of decompensation of cirrhosis and progression to acute-on-chronic liver failure (ACLF) and death.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination                                                                                                                 
Website: 
                                        												
																									
													https://www.microb-predict.eu/													
												                                                                        
                             	
								FeatureCloud
Privacy preserving federated machine learning and blockchaining for reduced cyber risks in a world of distributed healthcare
                                                Coordinator: Prof. Dr. Jan Baumbach, University of Hamburg (UHAM)                                                                        									                                                                            
Funding scheme: Horizon2020, 9 participants                                                                                                                
Duration: 60 months                                                                                                                
Start: 01.01.2019                                                                                                                 
Objective: Revolutionizing cloud communication - FeatureCloud is a novel artificial intelligence platform, based on a ground-breaking new cloud infrastructure for medical data exchange – totally anonymous by default.                                                                                                                 
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination                                                                                                         
                             	
								DynaMORE
Dynamic MOdelling of REsilience
                                                Coordinator: Prof. Dr. Raffael Kalisch, Leibniz Institute for Resilience Research, Germany                                                                        									                                                                            
Funding scheme: Horizon2020, 15 partners                                                                                                                
Duration: 66 months                                                                                                                
Start: 01.04.2018                                                                                                                
Objective: The overall aim of DynaMORE is to improve the prevention of, or quick recovery from, stress-related mental health problems. We hope to increase individual well-being, reduce healthcare demands and indirect economic costs, and contribute to a healthier society. An in silico model of stress resilience will be used as a basis for developing a novel mobile health (mHealth) product to prevent stress-related disorders and to support individuals in an effective and personalised way.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination                                                                                                                 
Website: 
                                        												
																									
													https://dynamore-project.eu/													
												                                                                        
                             	
								REPO-TRIAL
Improving the efficacy and precision of drug REPurpOsing TRIALs
                                                Coordinator: Prof Dr Harald Schmidt, MD PhD PharmD, FESC, Universiteit Maastricht, The Netherlands                                                                         									                                                                            
Funding scheme: Horizon2020, 9 partners                                                                                                                
Duration: 66 months                                                                                                                
Start: 01.02.2018                                                                                                                 
Objective: An in silico-based approach to improve the efficacy and precision of drug REPurpOsing TRIALs for a mechanism-based patient cohort with predominant cerebro-cardiovascular phenotypes                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination                                                                                                         
                             	
								Eat2beNICE
Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing Behaviours
                                                Coordinator: Dr. Alejandro Arias Vasquez, Radboud University Nijmegen, The Netherlands                                                                         									                                                                            
Funding scheme: Horizon2020, 18 partners                                                                                                                
Duration: 66 months                                                                                                                
Start: 01.09.2017                                                                                                                
Objective: The project's goal is to identify nutrition and lifestyle drivers that can be employed to prevent detrimental impulsivity/compulsivity in humans across the lifespan. The project aims to characterize the etiologic paths leading to extreme behaviour and promote policy changes to counteract maladaptive impulsivity/compulsivity by disseminating evidence-based information about health-related behaviours to families, clinicians, policy makers and the general public.                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination                                                                                                                 
Website: 
                                        												
																									
													https://eat2benice.eu/													
												                                                                        
                             	
								DISCOVERER
Disruptive Technologies for Very Low Earth Orbit Platforms
                                                Coordinator: Dr. Peter Roberts, University of Manchester, UK                                                                         									                                                                            
Funding scheme: Horizon2020, 9 partners                                                                                                                
Duration: 63 months                                                                                                                
Start: 1.1.2017                                                                                                                
Objective: Radical redesign of Earth observation platforms for sustained operation at significantly lower altitudes than the current state of the art, using a combination of new aerodynamic materials, aerodynamic control and airbreathing electric propulsion for drag-compensation, for a variety of observation methods with the aim of creating a new platform paradigm.                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, dissemination                                                                                                        
                             	
								RECAP preterm
                                                Coordinator:  Maaike Beltman, TNO innovation for life, Bergen op Zoom, NL                                                                        									                                                                            
Funding scheme: Horizon2020, 20 partners                                                                                                                
Duration: 57 months                                                                                                                 
Start: 1.1.2017                                                                                                                
Objective: to improve the health, development and quality of life of children and adults born very
preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) – approximately 50 000 births each year in Europe – by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and their families constituted from the early 1980s to the present, together with data from national registries.                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, dissemination                                                                                                                
Website: 
                                        												
																									
													https://recap-preterm.eu/													
												                                                                        
                             	
								LifeCycle
Early-life stressors and life cycle health
                                                Coordinator: Dr. Vincent Jaddoe, ErasmusMC, Rotterdam, NL                                                                        									                                                                            
Funding scheme: Horizon2020, 18 partners                                                                                                                
Duration: 66 months                                                                                                                
Start: 1.1.2017                                                                                                                 
Objective: To bring together pregnancy and child cohort studies into a new, open and sustainable EuroCHILD Cohort Network, to use this network for identification of novel markers of early-life stressors affecting health trajectories throughout the lifecycle, and translate findings into policy recommendations for stratified and targeted prevention strategies.                                                                                                                
Services of concentris: dissemination and website                                                                                                        
                             	
								CoCa
Comorbid Conditions of Attention deficit / Hyperactivity disorder
                                                Coordinator: Prof. Dr. Andreas Reif, Goethe University Frankfurt                                                                        									                                                                            
Funding scheme: H2020, 17 partners                                                                                                                
Duration: 66 months                                                                                                                
Start: 1.1.2016                                                                                                                
Objective: Understanding mechanisms underlying co-morbid disorders of Attention deficit / Hyperactivity Disorder (ADHD).                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, dissemination                                                                                                        
                             	
								BetaCure
Personalized diagnosis and treatment of hyperinsulinemic hypoglycaemia caused by beta-cell pathology
                                                Coordinator: Prof. Martin Gotthardt, Radboud University Medical Centre, The Netherlands                                                                        									                                                                            
Funding scheme: FP7, Collaborative Project, 17 beneficiaries                                                                                                                
Duration: 48 Months                                                                                                                
Start: 1.4.2014                                                                                                                
Objective: Familial hyperinsulinemic hypoglycemia (HHF) is a potentially fatal disease caused by hyperfunction of beta cells. A fatal course of the disease and severe brain damage are a major problem, especially in children with HHF. The BetaCure consortium wants to improve the treatment of this disease with the help of a clinical study. BetaCure will attempt to develop improved diagnostics and therapy using the imaging procedure. The misdirected beta cells in the pancreas are to be selectively excised or destroyed using image-guided diagnostics and surgery.                                                                                                                 
Services of concentris: Application, Contract Negotiation, Project Management, Dissemination                                                                                                        
                             	
								MATRICS
Multidisciplinary Approaches to Translational Research In Conduct Syndromes
                                                Coordinator: Dr. Jeffrey Glennon, Radboud University Nijmegen, The Netherlands                                                                        									                                                                            
Funding scheme: FP7, Collaborative Project, 19 beneficiaries                                                                                                                
Duration: 60 months                                                                                                                
Start: 1.3.2014                                                                                                                
Objective: To identify the neural, genetic and molecular factors involved in the pathogenesis of aggression/antisocial behaviour in (i) normally developing adolescents, (ii) children and adolescents with Attention-Deficit Hyperactivity Disorders (ADHD), and (iii) children and adolescents with Conduct Disorder (CD).                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, Dissemination.                                                                                                        
                             	
								MILESTONE
Managing the Link and Strengthening Transition from Child to Adult Mental Health Care
                                                Coordinator: Prof. Swaran Singh, Warwick Medical School, UK                                                                        									                                                                            
Funding scheme: FP7, Collaborative Project, 12 beneficiaries                                                                                                                
Duration: 60 months                                                                                                                
Start: 1.2.2014                                                                                                                
Objective: The overall objective of MILESTONE is to enhance the transition from the Child and Adolescent Mental Health (CAMHS) to Adult Mental Health (AMHS) Services  across Europe. The MILESTONE project is an EU-wide study determining care gaps in current services across diverse healthcare systems, robustly evaluating an innovative transitional care model and to create clinical, organisational, policy and ethics guidelines for improving care and outcomes for transition age youth.                                                                                                                 
Services of concentris: coordination of the application, contract negotiations, project management, Dissemination.                                                                                                        
                             	
								CAM-PaC
Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer
                                                Coordinator: Prof. Dr. Thomas Gress and PD Dr. Malte Buchholz, Philipps-University Marburg, Germany                                                                        									                                                                            
Funding scheme: FP7, Collaborative Project, 11 beneficiaries                                                                                                                
Duration: 60 months                                                                                                                
Start: 1.11.2013                                                                                                                
Objective: The overall aim of CAM-PaC is to use a strongly SME-driven approach to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate large scale metabolic, transcriptomic and genetic data from these models, in order to systematically identify, characterise and validate novel targets for therapeutic intervention and bioinfomatic models for predictive diagnostics.                                                                                                                 
Services of concentris: coordination of the application, contract negotiations, project management, Dissemination.                                                                                                        
                             	
								Aggressotype
Aggression subtyping for improved insight and treatment innovation in psychiatric disorders
                                                Coordinator: Prof. Barbara Franke, Radboud University Nijmegen Medical Centre, The Netherlands                                                                        									                                                                            
Funding scheme: FP7, Collaborative Project, 23 beneficiaries                                                                                                                
Duration: 60 months                                                                                                                
Start: 1.11.2013                                                                                                                
Objective: To gain a deeper understanding of different types of aggression in patients with ADHD, conduct disorder, as well as in the general population in order to better predict aggression development. In addition to the diagnostic-preventive approach, pharmacological as well as non-pharmacological means of personalized treatment will be tested.                                                                                                                 
Services of concentris: coordination of the application, contract negotiations, project management, Dissemination.                                                                                                        
                             	
								IMAGEMEND
IMAging GEnetics for MENtal Disorders
                                                Coordinator: Prof. Dr. Andreas Meyer-Lindenberg, Zentralinstitut für Seelische Gesundheit, Mannheim, Germany                                                                        									                                                                            
Funding scheme: FP7, Collaborative Project, 14 beneficiaries                                                                                                                
Duration: 48 months                                                                                                                
Start: 1.10.2013                                                                                                                
Objective: To improve the clinical management and aetiological understanding of mental illness through discovery of neuroimaging based diagnostic, trans-diagnostic and predictive markers and their translation into clinical tests and therapeutics.                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, Dissemination.                                                                                                                
Website: 
                                        												
																									
													https://www.imagemend.eu													
												                                                                        
                             	
								OPTIMISTIC
Observational Prolonged Trial In Myotonic dystrophy type 1 to Improve QoL-Standards, a Target Identification Collaboration
                                                Coordinator: Prof. Baziel van Engelen, Radboud University Nijmegen Medical Centre, The Netherlands                                                                        									                                                                            
Funding scheme: FP7, Collaborative Project, 8 beneficiaries                                                                                                                
Duration: 48 months                                                                                                                
Start: 1.11.2012                                                                                                                
Objective: To improve clinical practice in the management of patients with Myotonic dystrophy type 1 for which no dedicated treatment is currently available.                                                                                                                 
Services of concentris: coordination of the application, contract negotiations, project management, dissemination.                                                                                                        
                             	
								TACTICS
Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes
                                                Coordinator: Prof. Dr. Jan Buitelaar, Dr. Jeffrey Glennon, Radboud University Nijmegen, The Netherlands                                                                        									                                                                            
Funding scheme: FP7, Collaborative project, 11 beneficiaries                                                                                                                
Duration: 60 months                                                                                                                
Start: 1.2.2012                                                                                                                 
Objective: Compulsivity: A series of ‘proof-of-concept’ studies, the cohesion of structural neuroimaging studies, neurochemistry, behavior, genetics, proteomics and machine learning tools in paediatric clinical populations and behavioral animal models will seek to better understand underlying mechanisms related to glutamate dysfunction in frontostriatal circuits and its remediation / prevention by early intervention studies with glutamate-based clinically used drugs. 
                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, dissemination.                                                                                                        
                             	
								EMTICS
European Multicentre Tics in Children Studies
                                                Coordinator: Dr. Pieter Hoekstra, Academisch Ziekenhuis Groningen, The Netherlands                                                                        									                                                                            
Funding scheme: FP7, Collaborative project, 27 beneficiaries                                                                                                                
Duration: 66 months                                                                                                                
Start: 1.12.2011                                                                                                                
Objective: EMTICS will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles.                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, dissemination, training organization                                                                                                        
                             	
								CRESTAR
Pharmacogenomic biomarkers as clinical decision making tools for clozapine treatment of schizophrenia
                                                Coordinator: Prof. David Collier, King`s College London (Institute of Psychiatry), UK                                                                        									                                                                            
Funding scheme: FP7, SME-targeted collaborative project, 9 beneficiaries                                                                                                                
Duration: 48 months                                                                                                                
Start: 1.11.2011                                                                                                                 
Objective: CRESTAR is an SME-driven project focusing on the development of pharmacogenomic biomarkers for schizophrenia. It aims to develop tools to predict which patients will not respond to usual antipsychotics, and the 1% of patients who will develop potentially fatal side effects which is the main factor limiting clozapine use, and diabetic ketoacidosis, occurring in up to 2% of patients.                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, dissemination.                                                                                                        
                             	
								EPC-TM Net
European pancreatic cancer tumour microenvironment network.
                                                Coordinator: Prof. Dr. Thomas Gress, Philipps-Universität Marburg                                                                        									                                                                            
Funding scheme: FP7, Collaborative project, 15 beneficiaries                                                                                                                
Duration: 36 months                                                                                                                
Start: 1.2.2011                                                                                                                
Objective: The overall objective of this project is to improve survival of pancreatic cancer patients by exploring the contribution of the tumour microenvironment to the failure of presently available oncological treatments.                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management, dissemination                                                                                                        
                             	
								STOP
Suicidality: Treatment Occurring in Paediatrics
                                                Coordinator: Dr. Paramala Santosh, King’s College London, Maudsley Hospital, London, UK                                                                        									                                                                            
Funding scheme: FP7, Collaborative project, 16 beneficiaries                                                                                                                
Duration: 54 months                                                                                                                
Start: 1.11.2010                                                                                                                
Objective: The STOP project aims to develop a comprehensive web-based methodology for the assessment and monitoring of suicidality in children and adolescents.                                                                                                                 
Services of concentris: coordination of the application, contract negotiations, project management, dissemination, training organization                                                                                                                
Website: 
                                        												
																									
													https://www.stop-study.com													
												                                                                        
                             	
								MolDiag-Paca
Novel molecular diagnostic tools for the prevention and diagnosis of pancreatic cancer
                                                Coordinator: Prof. Dr. Thomas Gress, Philipps-Universität Marburg, Germany                                                                        									                                                                            
Funding scheme: FP6, Integrated Project, 21 participants                                                                                                                
Duration: 42 months                                                                                                                                                    
Objective: The overall aim of this project is to make use of genetic profiles of pancreatic cancer and precursor lesions to improve the outcome of pancreatic cancer patients by providing novel and highly efficient molecular diagnostic tools.                                                                                                                
Services of concentris: Third periodic and final reporting                                                                                                        
                             	
								BNEII
BrainNet Europe, Network of European Brain and Tissue Banks for Clinical and Basic Neuroscience
                                                Coordinator: Prof. Dr. Dr. h.c. Hans A. Kretzschmar, Ludwig-Maximilians-University Munich, Germany                                                                         									                                                                            
Funding scheme: FP6, Network of Excellence, 19 participants                                                                                                                
Duration: 66 months                                                                                                                                                    
Objective: BrainNet Europe is a consortium of 20 brain banks seeking to spread excellence in collecting human high quality post mortem brain tissue and to foster research in the cellular and molecular basis of neurological and mental disorders and diseases, gender aspects and the ageing process.                                                                                                                
Services of concentris: Project management, dissemination, training organization.                                                                                                        
                             	
								PRISM 2
Psychiatric Ratings using Intermediate Stratified Markers 2
                                                Coordinator: Prof. Dr. Martien Kas, University of Groningen, The Netherlands                                                                        																			
Project leader: Dr. Hugh Marston, Boehringer Ingelheim, Germany									                                                                            
Funding scheme: IMI2, Collaborative project, 14 partners                                                                                                                
Duration: 36 months                                                                                                                
Start: 01.06.2021                                                                                                                
Objective: The overall aim of PRISM 2 is to accelerate the development of effective treatments for patients suffering from neuropsychiatric disorders by implementing a quantitative, transdiagnostic neurobiological approach. The focus lies on researching the relationship between default mode network (DMN) integrity and social dysfunction in schizophrenia (SZ) and Alzheimer’s Disease (AD), and Major Depressive Disorder (MDD).                                                                                                                
Services of concentris: Coordination of the application, contract negotiations, project management, dissemination                                                                                                                
Website: 
                                        												
																									
													https://prism2-project.eu/													
												                                                                        
                             	
								EQIPD
European Quality In Preclinical Data
                                                Coordinator: Prof. Malcolm Macleod, The University of Edinburgh, United Kingdom                                                                        																			
Project leader: Dr. Thomas Steckler, Janssen Pharmaceutica NV, Belgium									                                                                            
Funding scheme: IMI2, 29 partners                                                                                                                
Duration: 48 months                                                                                                                
Start: 01.10.2017                                                                                                                
Objective: The project's aim is to enable a smoother, faster and safer transition from preclinical to clinical testing and drug approval by establishing common guidelines to strengthen the robustness, rigor and validity of research data.                                                                                                                
Services of concentris: Project management & Dissemination                                                                                                                
Website: 
                                        												
																									
													https://www.eqipd.org													
												                                                                        
                             	
								PRISM
Psychiatric Ratings using Intermediate Stratified Markers
                                                Coordinator: Prof. Dr. Martien Kas, University of Groningen, The Netherlands                                                                                                                
Managing Entity: Dr. Hugh Marston, Eli Lilly and Company Ltd                                    									                                                                            
Funding scheme: IMI 2, Collaborative project, 23 partners                                                                                                                
Duration: 36 months                                                                                                                
Start: 1.4.2016                                                                                                                
Objective: The PRISM project aims to unpick the biological reasons underlying social withdrawal, which is a common early symptom of, Schizophrenia, Alzheimer’s disease and Major Depressive Disorder, and thereby addresses the lack of understanding of the root biological causes which is one of the reasons behind the dramatic slowdown in the development of new drugs to treat neuropsychiatric disorders.                                                                                                                 
Services of concentris: coordination of the application, contract negotiations, project management, dissemination.                                                                                                        
                             	
								EMIF
European Medical Information Framework
                                                Coordinator: Bart Vannieuwenhuyse, Janssen Pharmaceutica, Belgium                                                                                                                
Managing Entity: Prof. Johan van der Lei, Erasmus Universitair Medisch Centrum Rotterdam                                    									                                                                            
Funding scheme: IMI, Collaborative project, 57 partners                                                                                                                
Duration: 60 months                                                                                                                
Start: 1.1.2013                                                                                                                
Objective: EMIF aims to develop a sustainable and scalable information framework which has the potential to access medical data on a scale and at a level of detail not currently available, thus opening avenues of research that so far have been out of reach. Two research questions – the identification of predictors and diagnostic biomarkers for Alzheimer’s Disease as well as for metabolic complications in adults and peadiatrics – will provide focus and guidance for the framework development.                                                                                                                
Services of concentris: coordination of the application, contract negotiations, project management                                                                                                                
Website: 
                                        												
																									
													https://www.emif.eu													
												                                                                        
                             	
								StemBANCC
Stem cells for Biological Assays of Novel drugs and prediCtive toxicology
                                                Coordinator: Martin Graf, F. Hoffmann-La Roche                                                                                                                 
Managing Entity: Dr. Zameel Cader, University of Oxford                                    									                                                                            
Funding scheme: IMI, Collaborative project, 35 partners                                                                                                                
Duration: 60 months                                                                                                                
Start: 1.10.2012                                                                                                                 
Objective: The aim of the STEMBANCC project is to generate and characterise 1,500 high quality human induced pluripotent stem (iPS) cell lines that can be used by researchers to study a range of diseases, including diabetes and dementia, and test for drug efficacy and safety. The cell lines will help to improve and speed up the drug development process, and ensure that patients benefit from more effective and safer drugs.                                                                                                                 
Services of concentris: coordination of the application, contract negotiations, project management, dissemination.                                                                                                        
                             	
								SATURN³
Spatial And Temporal Resolution of Intratumoral Heterogeneity in 3 hard-to-treat Cancers
                                                Coordinator: Prof. Jens Siveke                                                                        									                                                                            
Funding scheme: BMBF, 17 partners                                                                                                                
Duration: 60 months                                                                                                                
Start: 01.07.2022                                                                                                                
Objective: Tumours with marked tumour heterogeneity include triple-negative or luminal-B breast carcinoma (certain forms of breast cancer), as well as microsatellite-stable colorectal carcinoma (a subtype of colorectal cancer) and pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer). Among other things, the tumour heterogeneity makes these forms of cancer difficult to treat. In order to develop better treatment options here, a better understanding of the underlying mechanisms is needed. These are now being closely examined scientifically in the SATURN³ project.                                                                                                                 
Services of concentris: Coordination of the application, contract negotiations, project management                                                                                                                
Website: 
                                        												
																									
													https://saturn3.org/													
												                                                                        
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